How much later after starting a hypomethylating agent in an elderly patient with AML being treated in the upfront setting can venetoclax be started?  

It can safely be started at that time, but the outcomes may not be quite as optimal as when used from cycle 1. There is not much data about this, but when used after patients have had progression with prior exposure to hypomethylating agents, responses are sometimes not as robust (see ASH abstr...