How often do you monitor for pancreatitis (check lipase/amylase) while on Axitinib?  

I don't routinely measure amylase/lipase on axitinib or other TKIs. In the early days of sunitinib development, lipase was measured and often elevated without clinical symptoms. This led to unnecessary other labs and anxiety. I have a low threshold to measure in the right clinical context, but frank...

I do not screen for pancreatitis in the asymptomatic patients on either axitinib or axitinib/pembrolizumab. In the KEYNOTE-426 trial (axitinib/pembrolizumab versus sunitinib) clinical trial, the rate of pancreatitis in both arms was 0.5%. This is rare enough that I only investigate pancreatitis in s...