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How should the results of molecular/genetic tests for prostate cancer, be utilized in the post-prostatectomy setting?
There is a recent publication that nicely summarizes the molecular/genetic tests for prostate cancer (Ross et al., PMID 26123120). What should be done if molecular/genetic testing suggests potentially using an intervention where traditional indications are not met? For instance, an individual s/p radical prostatectomy without any of the traditional indications for post-RP adjuvant radiotherapy, but with a high risk Decipher score; would that push you towards adjuvant RT or would it just help you in the event that someone does have indications and is debating adjuvant vs potential eventual salvage?
Answer from: Radiation Oncologist at Academic Institution
The subject of molecular/genetic testing for prostate cancer is evolving, and a global discussion is beyond the scope of this format, but I'll address this issue in the setting of post-prostatectomy therapy. While tests such as Decipher may help to differentiate the risk of recurrence following prim...
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Answer from: Radiation Oncologist at Academic Institution
At this time, a score on decipher in the post op setting in a man with evidence of extraprostatic extension, positive margins or seminal vesicle invasion would not prompt the use of additional therapy but more close monitoring of PSA (q 3 mos) using an ultrasensitive assay
I hope this is helpful an...
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Radiation Oncologist at Lake Huron Medical Center
@Anthony V. D'Amico - Has your opinion...
@Anthony V. D'Amico - Has your opinion...