How would you approach a patient presenting with pancytopenia and splenomegaly whose bone marrow biopsy is morphologically normal but has a positive Philadelphia chromosome in bone marrow as well as peripheral blood?  

Given pancytopenia and splenomegaly, I’m surprised bone marrow is read as normal. Look for evidence of myelofibrosis in marrow by performing reticulin stain. How big is the spleen? This picture is consistent with CML. What is the blasts % in blood and marrow? What is the basophil %? I would t...

I would strongly consider a possibility that Ph' chromosome has no relationship to splenomegaly in this case. The latter could have an entirely different etiology.