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Thoracic Malignancies • Medical Oncology • NCI-CCC Tumor Board Question • Ohio State University
How would you approach a patient with Stage III EGFR+ NSCLC who develops oligometastatic disease while on consolidation durvalumab?
Given the potential high risk of developing pneumonitis with TKI post checkpoint inhibitor, do you avoid TKIs and try a different regimen (ex carbo/paclitaxel/bev +/- atezo)?
Answer from: Medical Oncologist at Community Practice
This is a difficult situation, I have typically tried local therapies like SBRT initially and then switching to osimertinib with close followup and return precautions
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