How would you approach a young patient with a history of APLS and VTE, desiring hormone replacement therapy after oophorectomy?  

I think the answer is not straightforward. What APLAs are positive and what was/is the titer? Were there other risk factors at the time of the clot (smoking, oral contraceptives, etc...) My general recommendation would be to avoid estrogens in patients with APLAs. I can imagine a scenario where the ...