How would you approach therapy for a SMARCA4-deficient undifferentiated sarcoma with isolated involvement of a mediastinal lymph node?

No primary thoracic mass identified. Knowing these often following an aggressive clinical course, would you consider concurrent chemo/RT, incorporate immunotherapy or advocate for surgery?

Answer from: Medical Oncologist at Academic Institution

This is a unique situation, but there is data to suggest that these thoracic tumors are actually sarcomatoid/de-differentiated carcinomas rather than true sarcomas. Rekhtman et al., PMID 31751681A smoking history or high tumor mutation burden on comprehensive genomic profiling would help with this d...

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Medical Oncologist at Frederick Onc Hem Assoc
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How would you approach therapy for a SMARCA4-deficient undifferentiated sarcoma with isolated involvement of a mediastinal lymph node?

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