Sarcoma
Questions discussed in this category
Assuming the patient is to get adjuvant RT for an R1 resection on the face, would you treat using electrons? Adequate depth would require at least 9Me...
Initial tumor causing cord compression and neurologic deficits.
The patient is a male in his 60s who underwent inguinal orchiectomy and spermatic cord resection of a 5 cm malignant fibrous histiocytoma of the sperm...
Would you cover the chest wall alone or would it be chest wall plus regional nodes?
Patient factors: no prior radiation therapy
When, if ever, do you utilize adjuvant RT or chemotherapy?
Would you recommend post operative radiation in an adult patient with a thoracic spine osteosarcoma?
S/P neoadjuvant chemotherapy and followed by oncologic surgical resection but with positive margins.
How do we approach patients with rare tumors given the paucity of data?
Would you consider using repretinib as first line therapy given its novel mechanism of action versus other treatment options?
The patient is in their 40s with right arm rhabdomyosarcoma s/p amputation. Path shows embryonal rhabdomyosarcoma 6.5 cm, margins neg. 11 of 19 lymph ...
Would you consider stopping therapy versus doxorubicin + dacarbazine/doxorubicin alone versus alternative chemotherapy ?
Sarcoma arose from Castleman disease
Would you prefer doxorubicin based chemotherapy or are alternative TKIs useful in this scenario?
If so, what dose/fractionation?
Pathology: High grade spindle cell sarcoma
Relevant pathology features: 7.5cm, grade 3 with a 5mm bronchial margin, negative nodes.
Relevant pathology features: positive margin
Total dose prescription: 66 Gy
Would non-gastric GISTs, high mitotic rate, large size, and young age of patient affect your decision? Especially knowing that TKIs suppress cell grow...
If there were negative margins, what other factors would you consider to add adjuvant RT? Size of the tumor or depth of invasion?
If so, which patients would you extend treatment?
Angiosarcoma is invading the brachial plexus and thoracic vertebral bodies.
Prior radiation therapy: Radiation to the left chest wall and regional no...
Patient initially achieved CR with VAC-IE with resolution of presumed lung mets and 100% necrosis in LLE primary tumor on BKA. Then was NED again afte...
What role, if any, does molecular testing play in diagnosis and management in the absence of available clinical trials?
How would you add radiation in your treatment paradigm? No clinical trials available due to age.
No lymph node dissection. cN0
Would your systemic therapy choice be more similar to treatment of ovarian carcinoma or soft tissue sarcoma?
If yes, would you offer neoadjuvant or adjuvant, concurrent or sequential?
Would you treat a knee?
Tumor factor: Large axillary soft tissue sarcoma with involvement of the brachial plexus
Other factor: Surgery would like to pursue upfront surgery t...
J Clin Oncol 40, 2022 (suppl 17; abstr LBA2). https://meetings.asco.org/abstracts-presentations/209024
Margins are negative (closest 4mm), grade 2, 3 of 23 lymph nodes positive with no extranodal extension. What is your preferred chemotherapy approach a...
The patient presented with spinal cord compression, had subtotal resection and instrumentation with metallic hardware. Main concern is that post op su...
4 cm with negative LN
No evidence of distant disease elsewhere. Surgical resection is not possible. Would you recommend metastasis direct therapy to the liver (i.e. SBRT or...
This was resected over 2 years ago with reconstruction of the IVC with a PTFE graft. No preop or postop RT given and the recurrence is in the area whe...
What dose would you use? For negative margins do you offer 50-50.4 Gy/25-28 fractions? What target volume margins do you typically recommend on t...
This patient is young and active but refuses palliative chemotherapy
Is there a role for pre-operative RT?
50+ yo F. Mastectomy, chemo, and RT in 2016 for primary breast angiosarcoma, not RT induced. Had longstanding cyst on wrist, biopsied, and positive fo...
Very rare tumor with sparse literature
Would you use gem/docetaxel, anthracycline-based regimens or targeted therapies?
Prior treatment: GTR in 2020, adjuvant radiation 63Gy
Patient factors: Medically inoperable and not fit for chemotherapy
The recurrence is within th...
And if so which?
Ewing sarcoma of the right lung, status post bi-lobectomy and adjuvant VDC/IE, with recurrence 6 years in the right lung only. He has reached a cumula...
What is the role for post-operative irradiation?
Would you change your management based on location, such as a sensitive area like the groin? What volumes do you recommend? Does age influence y...
Pathology did not meet criteria for a well-differentiated nor dedifferentiated liposarcoma, nor a spindle cell sarcoma.
Would you go beyond a traditional palliative regimen such as 30Gy in 10 fractions?
With conflicting data from the EORTC RCT and the Sarcoma meta-analysis collaboration, what factors determine when you would offer adjuvant chemotherap...
When chemotherapy is indicated in early stage soft tissue sarcoma, would you prefer to use AD or AI?
AD: doxorubicin + dacarbazine
AI: doxorubicin + ifosfamide
This is particularly relevant for patients with extensive delays due to wound healing issues.
The pulmonary metastases are planned to be addressed with a combination of surgical resection and SBRT.
Would you off more radiation if the prior pre-op radiation was within a few cm to the recurrence? If there a time interval you would wait before offer...
Does the degree of resectability affect your management?
How would you modify therapy for a younger, fit patient versus an older, frail patient?
Lesions in stomach, small intestine, colon resulting in bleed...
40 yo adult patient with a~6cm mass with concern for skull base bony involvement (group III and stage III, no nodal involvement )
Received optimal pre-op denosumab; only option is now amputation
When do you offer preop RT (50Gy) before the re-excision? When do you offer post-op RT after the re-excision?
Individuals often cite ARST0332 to justify radiation omission in high grade R0 resections, but R0 was defined as > 5 mm margins.
If a staging RPLND is NOT performed, is there a role for prophylactically irradiating the lymph nodes, even in the setting of a negative PET/CT at dia...
Would you consider SBRT?
What would be your radiation volumes/dose and choice of chemotherapy?
Would you offer adjuvant RT or chemotherapy? If so, what chemotherapy would you prefer?
If so, what dose and treatment fields would you use?
AIM or doxorubicin/cisplatin? Would you recommend adding methotrexate?
Would your treatment approach be similar for a patient with suboptimal performance status?
How do you incorporate PD-L1 blockade?
In particular, is there any data on the efficacy of Ipilimumab/Nivolumab?
Given that risk definitions are based on size, mitotic activity, location and not necessarily genetics/biology, would an otherwise low-risk GIST, who ...
What factors make you more likely to offer or omit chemotherapy?
What is the role for adjuvant versus neoadjuvant chemotherapy?
Does ER/PR status help guide your decision?
No sarcomatous overgrowth seen.
Patient with hepC and advanced cirrhosis with multiple liver mets, but may be able to tolerate oral TKI or PARP. Would you offer this or focus on hosp...
These tumors are often low grade, but have a propensity for local recurrence.
Performance status is excellent. Second surgical opinion has also confirmed need for amputation, as the recurrence is now breaching intra and extra ar...
Osteosarcoma conventional type of the distal right femur. cT1N0M0 G3 Stage IIA on MAP protocol completed NACT followed by surgery on radical resection...
What margin would you consider to be necessary to omit radiation?
Patient received Pazopanib upfront with Ifos/Dox. Pulmonary metastatectomy is not an option as there are multiple mets.
This patient had resection of the primary, requiring multiple resections to obtain an R0 resection, followed by adjuvant radiation to the primary. The...
Is chemoradiation a viable strategy in osteosarcoma?
Since desmoid tumors are associated with high estrogen states, is there an optimal contraception approach? Is there an optimal time for pregnancy? How...
Would you consider doing a pre-op RT prior to possible re-excision? If yes, what dose would you give? If the location is between L4-L5 spine.
At what lower end of recurrence risk do you offer adjuvant imatinib for patients with resected GIST?
What is your preferred risk stratification model?
There does not appear to be a consensus among experts as to what cutoff in recurrence risk ju...
Mets to spine and s/p RT
How do you interpret the results from the recently published EORTC-62092: STRASS study that showed no benefit to preop RT+surgery vs surgery alone and...
In this patient dermatofibrosarcoma protuberans of the thoracic spine, which originally caused a cord compression and has since been debulked, gross r...
Do you switch to alternative TKI? Dose reduce?
Post-auricular cutaneous angiosarcoma, pT1 (19 mm) with negative margins. Unclear if there is any indication for systemic therapy, given early stage a...
Assuming no access to clinical trial
For example, gastric GIST, < 5 mitoses/hpf and size > 5 cm but < 10 cm is intermediate by NIH criteria but low by NCCN/CAP criteria. Th...
If post-op with clear margins would you prefer adjuvant RT or close observation with surgery for optimal reduction of local recurrence? This particula...
> 7cm, grade 3. If chemotherapy offered, what is your preferred adjuvant therapy?
>10 cm, no metastatic disease identified on staging scans
What if the patient had also received HIPEC prior?
How do you sequence systemic therapy with radiation and surgery?
For e.g. how many cycles of ifos/doxorubicin do you administer in this context?
Nearly 11 cm in size
No primary thoracic mass identified. Knowing these often following an aggressive clinical course, would you consider concurrent chemo/RT, incorporate ...
Would you consider adjuvant chemotherapy, radiation therapy, hormone therapy, or surveillance?
Final pathology showed grade 3 spindle cell sarcoma of thee vagina involving the anterior lateral cervix 5.6cm x 4.5 x 3.4cm, <0.1cm left lateral m...
How does histology, time to distant Mets affect your decision?
In patients with symptomatic disease that observation would not be appropriate, what is your preferred treatment?
Which Radiation modality, if any, would be preferred?
Typical chemotherapy does not work for SFT. In which circumstance would you use VEGF ( Temozolo...
Would you consider "neoadjuvant" hormonal therapy to shrink tumors and potentially make more amenable to complete cytoreduction at a later date?
Woul...
Recent results from the STRASS trial suggest limited benefit from preoperative radiation therapy for retroperitoneal sarcomas.
https://pubmed.n...
Potentially, if metastasis responds, could be treated with surgery or radiotherapy
If you do what dose and fractionation do you recommend?
Presented with mass projecting into right/left anterior ethmoid complex
The patient previously received the P6 regimen.
Data suggest patients with D842V-mutated or KIT/PDGFRA WT GIST do not respond to imatinib, but NCCN guidelines does not take into consideration mutati...
More specifically there is no testicular invasion - would you cover the entire scrotal sac? What lymph node stations if any would you cover?
The interval since prior resection is between 3-5 years. Additionally, there is some evidence of nodal involvement but no evidence of metastatic disea...
Re-excision would result in amputation. And the patient had attempted pre-operative RT but quit at 16Gy due to toxicity/social reasons. Would you trea...
>5cm. If so, what is your preferred regimen?
Would you use general sarcoma expansions or would smaller expansions like the ones in head and neck would be reasonable?
Pleomorphic sarcoma
Would chemotherapy be a consideration? If yes, would you adjust margins or dose?
Specifically, when treating a tumor located in the head and neck region, would you consider treating closer to 64-66 Gy? Or would you be consistent wi...
When deciding to treat what would be your dose/volumes? And would a re-staging scan play a role in your treatment planning?
If a patient with a high grade sarcoma has gross residual/recurrent disease after resection and cannot undergo further surgery - would you boost this ...
Any strong considerations for infusional vs. bolus doxorubicin?
Should treatment be based on current histology (rhabdomyosarcoma) or origin (germ cell)?
What is your regimen? And long-term follow-up in these patients?
What if it was status post partial resection? And had bilateral level 2 lymph nodes?
Would you consider using recently approved agent for symptomatic / unresectable PN, Selumetinib prior to Systemic Chemotherapy in this setting?
How are you modifying your current sarcoma-directed therapy in the setting of the COVID-19 pandemic?
For example, would you consider switching to an outpatient regimen in lieu of AIM for metastatic soft tissue sarcoma?
Would you consider regorafenib based on the REGOBONE trial? Or would you consider other agents knowing that we do not have positive survival data with...
What dose schedule would you use to treat plantar fibromatosis? How soon after resection would you begin treatment? And how happy were you with the re...
Would you even consider trabectedin in this case given its cardiotoxicity?
Tumor 13 cm on back with retiform and kaposiform features; all margins negative except one abuts inked margin; atypical cells with 4 mitosis/HPF.
Add...
Do you proceed to resection or palliative chemotherapy?
MRI with intravaginal gel shows no gross residual disease.
The case in question is a radiation-induced spindle cell sarcoma at the thoracic spine previously treated for a plasmacytoma to a dose of 60 Gy in 30 ...
For both the primary and re-resection surgeries, resection was achieved via both scrotal and inguinal incisions. And margins were reported as negative...
Sometimes wound healing can delay adjuvant radiotherapy by several months. For aggressive histology, such as high grade sarcomas or skin cancers with&...
How do you choose between single-agent or combination chemotherapy versus newer treatment strategies such as palbociclib?
How, if any, do you utilize genomic testing to guide systemic therapy?
Adverse features include increased nuclear size, nuclear atypia, and mitotic activity up to 10/50 HPF.
How do you approach pathologic review and genomic testing, if indicated, of a spindle cell neoplasm?
For example, if a biopsy reads: lesion comprised of spindle cells arranged in a fascicular pattern, elongated, hyperchromatic nuclei, focally positive...
Would your recommendations change in the neoadjuvant versus adjuvant or metastatic setting?
i.e. doxorubicin, ifosfamide + RT. Do you worry about decreased locoregional control or increased toxicities with the use of G-CSF in combination with...
If so, would you treat the whole pelvis, cuff brachytherapy, or both?
Recurrence is in the radiation field right at the border of graft and scalp, and started to surface at about 20-24 Gy. It is visibly enlarging over se...
Do you reduce the dose to <400 mg daily or employ dosing schedules?
What is your preferred neoadjuvant chemotherapy course for healthy adult patients with osteosarcoma?
Is there an age limit you use to consider MAP? Would you consider using AIM instead?
How do you choose between local therapy (surgical debulking or ablation) v. 2nd line systemic therapy? Would you consider immunotherapy?
Would certain patient/disease characteristics make you choose RT therapy over chemotherapy or other locally ablative therapies? What dose/fraction wou...
How do you treat if adriamycin is not an option?
Specifically concurrent ifosfamide? Induction AIM?
Given metastatic disease and not a trial candidate, how would you approach this scenario? How does an underlying diagnosis of NF1 affect your decision...
Did the publication earlier this year by Gundle et al. JCO 2018 (http://ascopubs.org/doi/pdf/10.1200/JCO.2017.74.6941) alter your concept of close mar...
What margins (if any) do you consider appropriate to not require adj RT? And would you ever consider neoadj RT?
NCCN suggests to consider continuation of imatinib from some single/multi institution non-randomized trials for ~2 years, but does not suggest what fa...
Specifically the groin region? Or are there techniques or a change in the management style of radiation at these sites you would employ to minimize to...
If so, how do you choose your region of treatment? Dose? And elective nodal volume?
No actionable mutations were identified on next generation genomic sequencing.
How would you treat metastatic, unresectable, solitary fibrous tumor in a patient with mild hemophilia A? Each anti-VEGF medication comes with a warni...
If margins are clear, would this tumor necessitate adjuvant radiotherapy? Synovial sarcomas often occur in a young patient subset, would this cause yo...
Do you use chemotherapy or radiation?
Do you treat retroperitoneal sarcomas with a boost to the rind (or suspected close surgical margin)?
If so, what patients do you select for the boost? And what data do you give to adequately satisfy the insurance review and win approval?
How does grade or performance status affect your treatment decisions?
Does anatomic location (eg retroperitoneal or thoracic) affect your treatment decision?
In a patient, with multiple small volume lesions (5-25mm), would you offer pelvic RT?
Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...
After and extensive en bloc resection, is there further surgery that would be recommended? Is radiation alone sufficient?
Would you treat these sites to definitive or post-operative doses? If not, is there a dose constraint you use at these sites? Do you use tighter margi...
I have seen favorable clinical trial reports on dasatinib for metastatic disease, but no data on possible adjuvant use. NCCN guidelines suggest ...
What other pathologic features may you use to guide therapy decisions (eg mitoses/grade or NGS)? If you decide on adjuvant therapy, what regimen...
Is there a role for adjuvant radiation? Other chemotherapy options?
What things would you take into consideration for the simulation set-up? Specific instructions for treatment planning? If the PTV is confined to only ...
Is there a role for immunotherapy outside of trial setting?
Is there any data to suggest delayed initiation of adjuvant treatment would be beneficial? Or would close surveillance be reasonable? Patient is asymp...
Patient currently has bone and lung metastasis.
Is breast conserving surgery followed by radiation therapy an option?
CIC-DUX4 fusion sarcoma is a rare entity, the aggressiveness of which is comparable to Ewing's sarcoma. A major dilemma is whether to treat these pati...
Do you follow pediatric protocols or treat this more like a high grade soft tissue sarcoma? Specifically for paratesticular pleomorphic RMS, do you ad...
Is a margin of 5 cm on the GTV still standart?
What are some guidelines or principles that you use to recommend adjuvant radiation after complete resections of sarcoma?
For example, in the setting of a lack of pre-operative imaging, what CTV margin(s) would you utilize for the initial and boost phases of treatment?
How does grade, margin status, and previous radiation dose factor into the recommendation?
What time delay would make the benefit of adjuvant therapy likely no longer significant?
Would it differ if the tumor was high grade at the same location?
Do you offer neoadjuvant RT with resection and node dissection vs. definitive radiation? How extensive does the nodal disease have to be for you...
Tumor involves stomach, liver, and lymph nodes. Pathology is suspicious for sarcomatoid carcinoma, possibly sarcomatoid cholangiocarcinoma.
Is there any role for consolidative RT/CRT to the lung and mediastinum after initial chemo? What dose and fractionation would be most appropriate for ...
Should such a case be treated like retroperitoneal sarcoma?
If so, how to you address the scar? Do you use bolus? Do you place a 2mm retraction from skin for the target contour?
Are there clinic trials that look promising for patients with leiomyosarcoma?
If so, to what dose?
With the high rates of recurrence postoperatively with angiosarcomas of the scalp, adjuvant radiation is often recommended. What margins would y...
Most guidelines discuss target delineation and contouring recommendations for extremity sarcomas, which generally suggest larger longitudinal than rad...
For example, a patient with liposarcoma of the lower extremity status post preoperative radiation to 50 Gy who then underwent resection and had focall...
Can you use SBRT for boost?
Would the dose change based if there was tumor adherent to bowel versus abdominal wall or muscle?
Would the histological grade or histology affect the dose? Would you consider dose escalating to the center of the tumor if this would not affect orga...
I am treating a resected high grade liposarcoma with positive surgical margins to 66Gy. I would prefer to use IMRT to spare the humerus, but ...
What is the risk of joint issues if you treat the epitrochlear nodes?
When the disease (in this case, lymphoma) involves almost all of the entire muscle compartment of the distal lower extremity, what is a safe dose? I'm...
And does your dose changes with positive margins? I can't seem to find a good answer in the literature.
Papers discussed in this category
Cancer, 2021 Oct 13
International journal of radiation oncology, biology, physics, 2012-07-15
Cancer, 1986-09-01
Cancer, 2010-03-15
International journal of radiation oncology, biology, physics, 2015-07-01
Lancet, 2002-06-29
The Lancet. Oncology, 2016-07
Cancer, 2006-07-15
JAMA Oncol,
Journal of radiation oncology, 2016
International journal of radiation oncology, biology, physics, 2007-04-01
The Journal of bone and joint surgery. American volume, 2009-03-01
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992-01
Int J Radiat Oncol Biol Phys, 2012 Nov 1
Cancer, 2003-04-15
International journal of radiation oncology, biology, physics, 2002-03-01
J Surg Oncol,
Breast Cancer Res. Treat.,
J. Clin. Oncol.,
International journal of radiation oncology, biology, physics, 1993-10-20
Int. J. Radiat. Oncol. Biol. Phys.,
Radiother Oncol,
Eur. J. Cancer, 2014 Apr 11
Radiat Oncol, 2017 Jan 26
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008-07-10
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998-01
Annals of surgery, 1982-09
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-07-10
Radiother Oncol,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1996-03
Practical radiation oncology, 2016
Int. J. Radiat. Oncol. Biol. Phys.,
J Natl Med Assoc,
Ann Palliat Med,
Int. J. Radiat. Oncol. Biol. Phys.,
International journal of radiation oncology, biology, physics, 1993-12-01
Clin. Cancer Res.,
The Lancet. Oncology, 2009-11
Ann. Surg. Oncol., 2015 Feb 05
Oral Oncol., 2013 Nov 15
Cancer, 2009-07-15
Cancer, 2011-10-01
Hematol Oncol Clin North Am, 2019 Oct 28
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003-04-15
Cancer, 2011-06-15
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-09-20
The Lancet. Oncology, 2016-10
Cancer,
J Clin Oncol, 2018 Jan 18
Ann. Surg. Oncol., 2018 Oct 01
Clin. Orthop. Relat. Res.,
Eur. J. Cancer,
International journal of radiation oncology, biology, physics, 2015-08-01
American journal of clinical oncology, 2016-12
Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-04-15
Int J Clin Exp Med, 2015 Sep 15
Pathol. Int.,
Oncotarget,
Cancer,
Cancer medicine, 2019-01
Tumori,
Thromb. Haemost.,
Cancer, 2010-10-01
European journal of cancer (Oxford, England : 1990), 2013-03
American journal of clinical oncology, 2019-01
World J. Gastroenterol.,
Ann Surg Oncol, 2014 Aug
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2018-05-23
Acta Oncol, 2017 Apr 21
Lancet Oncol., 2017 Sep 04
Lancet Oncol., 2012 Sep 04
European journal of cancer (Oxford, England : 1990), 2012-06
Annals of surgery, 2007-10
Annals of surgery, 2012-02
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010-06
Int. J. Radiat. Oncol. Biol. Phys.,
Br. J. Dermatol., 2014 Nov 10
The New England journal of medicine, 2018-12-20
Journal of the American Academy of Dermatology, 2018-11
Am. J. Surg. Pathol.,
Cancer,
Am. J. Surg. Pathol.,
Ann Diagn Pathol,
Ann. Oncol., 2012 Feb 13
Cancer, 2011-11-01
Case reports in oncology, 2017
BMC Cancer, 2015 Oct 15
Gynecologic oncology, 2003-07
Obstetrics and gynecology, 2013-09
Lancet Oncol.,
Gynecol. Oncol., 2005 Dec 20
Int J Gynecol Cancer,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997-06
Practical radiation oncology, 2015
J Med Imaging Radiat Oncol, 2014 Apr 14
British journal of haematology, 2017-08
Lancet Oncol., 2018 Nov 23
Ann. Oncol., 2011 Apr 28
Lancet Oncol., 2020 Feb 17
Sarcoma, 2020 Jan 30
Clin. Cancer Res., 2020 Feb 13
Radiother Oncol, 2016 May 17
International journal of radiation oncology, biology, physics, 2009-07-01
International journal of radiation oncology, biology, physics, 2005-11-01
JAMA Oncol, 2020 Feb 20
International journal of radiation oncology, biology, physics, 2009-01-01
International journal of radiation oncology, biology, physics, 2011-07-01
Eur J Cancer,
Int. J. Radiat. Oncol. Biol. Phys.,
Eur J Surg Oncol,
Gynecologic oncology, 2001-10
Int. J. Gynecol. Pathol.,
Eur. J. Cancer, 2008 Apr 02
J Clin Oncol,
International journal of radiation oncology, biology, physics, 2002-02-01
Surgical oncology clinics of North America, 2013-07
International journal of radiation oncology, biology, physics, 1993-03-15
Translational gastroenterology and hepatology, 2017
Surg Oncol, 2016 May 10
Journal of cutaneous pathology, 2014-11
Sarcoma, 2014
Int. J. Radiat. Oncol. Biol. Phys., 2018 Aug 02
Lancet Oncol., 2017 May 09
Annals of surgery, 2016-05
Lancet Oncol., 2020 Sep 14
Ann. Surg.,
Lancet Oncol,
International journal of radiation oncology, biology, physics, 2015-08-01
Cancer, 2019-04-15
Ann Surg Oncol, 2017 Sep 11
Annals of plastic surgery, 2013-12
J Thorac Oncol, 2019 Nov 18
ESMO Open,
International journal of radiation oncology, biology, physics, 2012-05-01
Cancer, 2017-06-15
Eur J Cancer, 2020 Dec 07
Cancer, 2014-04-01
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-11-20
Oncologist, 2020 Dec 01
The Lancet. Oncology, 2018-03
The Lancet. Oncology, 2019-06
J Hematol Oncol, 2016 Jun 03
The Lancet. Oncology, 2017-11
Annals of oncology : official journal of the European Society for Medical Oncology, 2014-12
Int J Oral Maxillofac Surg,
Neurosurg Clin N Am, 2020 Apr
J Clin Oncol, 2012 Feb 13
Ann Oncol, 2013 Apr 04
Cancer, 2018 Sep 14
Annals of surgery, 2014-05
Clin Cancer Res, 2021 Mar 25
Oncologist, 2018 Dec 12
International journal of radiation oncology, biology, physics, 2012-02-01
Pediatr Blood Cancer, 2016 Mar 22
Lung Cancer, 2016 Apr 26
Eur J Cancer, 2015 Feb 13
J Surg Oncol, 2020 Oct
Clin Sarcoma Res, 2013 Dec 18
Int J Radiat Oncol Biol Phys, 2020 Apr 11
J Surg Oncol, 2014 Aug 11
Int J Radiat Oncol Biol Phys, 2010 Jan 07
International journal of radiation oncology, biology, physics, 2011-07-01
Cancer, 2014 Jun 03
Am J Surg Pathol, 2021 Jun 03
Journal of surgical oncology, 2014-08
International journal of radiation oncology, biology, physics, 2018-08-01
The American journal of surgical pathology, 2008-01
Int J Part Ther, 2021 Jun 25
Lancet Oncol, 2019 Nov 27
Practical radiation oncology, 2019-01
Clin Transl Radiat Oncol, 2020 Nov
Sarcoma, 2019
Annals of surgical oncology, 2007-06
American journal of clinical oncology, 2013-04
J Clin Oncol, 2008 Sep 22
Annals of surgery, 2004-10
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2014-12
Sarcoma, 2010 Mar 08
Cancer Med, 2021 Jun 04
International journal of radiation oncology, biology, physics, 2013-07-01
Pediatr Blood Cancer, 2022 Oct 02
Clin Cancer Res, 2023 Jan 09
Radiation oncology (London, England), 2019-06-06
Clin Oncol (R Coll Radiol), 2004-06-01
G Ital Dermatol Venereol, 2014 Feb
Clinical orthopaedics and related research, 2014-03
Cancer, 2011 Jan 18
Am J Clin Oncol, 2019 10
ESMO Open, 2021 Jun 02
Adv Radiat Oncol, 2022 Feb 05
Acta orthopaedica Scandinavica, 1984-06
Practical radiation oncology, 2016
Pract Radiat Oncol, 2021 Jul 26
Int J Radiat Oncol Biol Phys, 2009 Apr 11
Lancet Oncol, 2020 Jul 20
Updates Surg, 2016 Aug 08
Ann Surg Oncol, 2022 Jan 08
Pediatric blood & cancer, 2018-02
Cancer control : journal of the Moffitt Cancer Center, 2013-10
J Surg Oncol, 1981
Clin Case Rep, 2021 Nov 16
Clin Case Rep, 2015 Nov 23
The American journal of cardiology, 2018-12-01
Curr Oncol, 2021 Oct 13
Cardiooncology, 2019 Jan 29
International journal of radiation oncology, biology, physics, 2005-11-15
J Adolesc Young Adult Oncol, 2019 Nov 08
Eur J Cancer, 2017 Nov 28
European journal of cancer (Oxford, England : 1990), 2007 Jan 30
JAMA oncology, 2018 Jan 01
Clinical cancer research : an official journal of the American Association for Cancer Research, 2021 Feb 25
Clinical cancer research : an official journal of the American Association for Cancer Research, 2021 May 14
European journal of cancer (Oxford, England : 1990), 2011 Jun 22
World journal of surgery, 2003-07
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016-12
The Lancet. Oncology, 2022 Mar 10
JAMA oncology, 2021 Jan 21
The Lancet. Oncology, 2014 Mar 05
European journal of cancer (Oxford, England : 1990), 2019 Jan 25
Current treatment options in oncology, 2023 Apr 05
Cancer, 2019-09-15
Acta oncologica (Stockholm, Sweden), 2021 Sep 23
Radiation oncology (London, England), 2019 Jan 29
American journal of clinical oncology, 2017-12
American journal of clinical oncology, 2006 Jun