How do you approach adjuvant treatment of non-uterine leiomyosarcoma?   

I do not offer adjuvant chemotherapy to persons with leiomyosarcoma. One can make a case that the large negative randomized study EORTC 62931 published in 2012 supplants the 2008 meta-analysis of smaller studies that showed survival benefit from adjuvant chemo. Woll et al., PMID 22954508Neither...

I approach non-uterine LMS the same way I approach other soft-tissue sarcomas. Radiation is utilized if margins are close. In the extremity the hope is for 2cm of margins, but at least 1 cm. Anything less than that should get radiation to improve local control (Bean et al., PMID 24756814). In the re...