How would you treat unresectable angiosarcoma of the extremity in a patient who is inoperable due to underlying comorbidities?  

Radiation and taxane therapy are both active agents for angiosarcoma. Administering weekly paclitaxel is supported by the ANGIOTAX study (Penel et al., PMID 18809609), and @Matthew B. Spraker and colleagues are conducting a phase II trial evaluating the efficacy of induction chemotherapy followed by...

I generally agree with @Adam Olson’s thoughtful response. Assuming this is cutaneous, I would also obtain systematic mapping punch biopsies around the lesion to define extent of microscopic spread, which can extend further than appreciated on MRI. Following that, induction taxane-based chemo...