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How would you treat a primary angiosarcoma arising in the skull, excised with initial excisional biopsy?

Would you recommend oncologic resection? Would you do neoadjuvant chemo and/or radiation (concurrent or sequential)? Pre-op radiation volumes would be smaller and lower dose to brain.
2 Answers
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Radiation Oncology · The Ohio State University - James Cancer Hospital and Solove Research Institute
Answered on

I would try to get some more information first. Is this a cutaneous primary invading into skull, or a lesion arising primarily in the skull? Is there any evidence of violation (tumor or iatrogenic) through calvarium such that dura is threatened? I would stage with a careful skin exam for any cutaneo...

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Medical Oncology · University Hospitals
Answered on

Since this tumor has been resected, I would recommend oncologic resection with WLE followed by post-op RT. The surgical bed has been contaminated in this case with an unplanned resection, hence pre-op RT will likely not serve the purpose- most data comes from extremity sarcoma anyways and we usually...

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