Would you use neoadjuvant TKI or neoadjuvant radiation for a large chest wall sarcoma with an NTRK fusion on NGS?  

Although there is no data to support the "neoadjuvant" use of NTRK inhibitors in NTRK-fused sarcomas, the rapidity of response to this approach is amazing. There is also a school of thought that the use of NTRK inhibitors in NTRK-fused sarcomas affords a durable response. My experience is different....