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Would you recommend post operative radiation in an adult patient with a thoracic spine osteosarcoma?
S/P neoadjuvant chemotherapy and followed by oncologic surgical resection but with positive margins.
Answer from: Radiation Oncologist at Academic Institution
The following answer is extrapolated from AOST2032 which is a pediatric clinical trial but is relevant to the question at hand.
This case touches upon the concepts outlined in the AOST2032 research protocol for osteosarcoma radiation therapy. While acknowledging this is just one protocol and ...
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Answer from: Radiation Oncologist at Academic Institution
There are many details that would be important to know here (location of positive margin; can the positive margin be revised; what chemo given; % necrosis/response to chemo; subtype, etc) but from first principles, absolutely yes to adjuvant RT. Adjuvant RT has shown benefit in H&N osteosarcoma ...