What is the recommended treatment approach for stage III/IVA nasopharyngeal cancer that is p16 negative and EBV positive?  

The recommended treatment approach for stage III/IVA EBV-positive nasopharyngeal cancer is induction chemotherapy with gemcitabine/cisplatin followed by concurrent chemoradiotherapy with cisplatin.This was established in a phase 3 trial that compared induction chemotherapy plus concurrent chemoradio...

While the paper from NEJM is compelling, the authors follow up in 2022 with their "final" analysis in JCO Zhang et al., PMID 35709465 The overall results hold up, with an ~9% absolute OS improvement at 5 years; however, they did do a subgroup analysis by serum free EBV-DNA dividing by >4000 cop...