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Radiation Oncology • Sarcoma
When do you recommend preop RT for retroperitoneal sarcomas?
How do you interpret the results from the recently published EORTC-62092: STRASS study that showed no benefit to preop RT+surgery vs surgery alone and with higher toxicity in the RT+surgery arm?
Answer from: Radiation Oncologist at Academic Institution
I imagine I'm not alone in feeling a tad frustrated with the STRASS trial results, not because of the negative primary endpoint in regards to radiotherapy, but because it failed to clearly answer the question it was supposed to.In brief, the STRASS trial was a 2-arm randomized controlled trial of su...
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Answer from: Radiation Oncologist at Academic Institution
The STRASS study of surgery versus RT + surgery had obvious impact on our field. I think it is good, however, to keep in mind the limitations of the study and the reported outcome at this time (ACRO meeting 2020 - Sarcoma session, DeLaney et al., PMID 33387499). I look forward to the continued outco...
Answer from: Radiation Oncologist at Academic Institution
STRASS did not show "no benefit" from preop RT. On the contrary, every piece of data we have--including STRASS--suggests about a 50% reduction in local recurrence rates with preop RT for STS. That number is remarkably consistent across studies. These studies include:1. STRASS itself, appendix p...