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Sarcoma • Medical Oncology
When should adjuvant chemotherapy be offered to patients with soft tissue sarcoma of the extremity?
With conflicting data from the EORTC RCT and the Sarcoma meta-analysis collaboration, what factors determine when you would offer adjuvant chemotherapy to patients with soft tissue sarcoma of the extremity?
https://www.ncbi.nlm.nih.gov/pubmed/9400508
https://www.ncbi.nlm.nih.gov/pubmed/22954508
How do you sequence chemotherapy and radiation?
Answer from: Medical Oncologist at Academic Institution
The disclaimer is, this continues to be an area of debate and discussion. Having said that, the best I can do in this forum/format:
Good PS, normal organ function, high-risk STS (stage 3), extremity/superficial trunk location, excluding low/non-responsive histologies (e.g. CSS, ASPS, SFT...) should...
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Answer from: Medical Oncologist at Academic Institution
This is a complex question without a singular answer. I would suggest taking a look at the more recent neoadjuvant publications including the one belowPasquali et al., PMID 34643947.