What is your approach to adjuvant systemic therapy for radiation-induced epithelioid angiosarcoma of the chest wall after successful margin-negative resection?  

I generally prefer to give neoadjuvant paclitaxel, but in cases such as this where a patient has undergone a margin negative resection, I discuss the limited data supporting adjuvant chemotherapy and after that discussion, will often offer gemcitabine + docetaxel for higher-risk patients, particular...