Would you consider neoadjuvant ifosfamide-based chemotherapy for a large (>10cm) high grade soft tissue extremity sarcoma in an attempt to achieve limb sparing surgery in an otherwise healthy young patient?  

This question is similar to one previously posted:Are there any types of sarcomas that you use induction and/or concurrent chemotherapy with radiation prior to surgery?In cancers where chemotherapy confers a survival benefit (e.g. breast, osteosarcoma), chemo before or after surgery is fine. I would...