How would you manage an osteosarcoma patient with local disease only and an R0 resection who could not tolerate neoadjuvant chemotherapy?  

I wouldn't consider this an indication for radiotherapy, but I would proceed with an alternative chemotherapy. There are many places where the use of MAP is challenging due to limited resources and so alternative regimens are required. We evaluated carboplatin, ifosfamide, and doxorubicin in the abs...