Would you offer adjuvant chemotherapy for a large, high-grade radiation-induced malignant peripheral nerve sheath tumor following R1 resection?  

I assume a post op scan shows no gross disease. Technically this is not "adjuvant" since there is known microscopic residual disease. In a young patient with good PS and organ function, it's reasonable to discuss risks and benefits of systemic chemotherapy (Doxorubicin + Ifosfamide) now vs. close f/...

While it might be argued that neoadjuvant chemotherpy or radiation might have facilitated complete resection and a chance for cure, I do not believe that we have any evidence that chemotherapy or radiation for residual disease at the margin of resection and possibly micrometastatic disease offers an...

The decision for adjuvant chemotherapy is ultimately shared decision-making with the patient. We generally recommend doxorubicin 75-90 mg/m2 by 72 hr infusion or bolus with dexrazoxane plus ifosfamide 10 gm/m2 over 4-5 days.