How do you manage a soft tissue sarcoma arising from neurofibromas (NF1)?  

Great question! Sarcoma (STS) arising in the setting of NF1 can be challenging.I usually recommend for preop XRT, image-guided RT for STS should be 50 Gy in 2 Gy/fx:GTV = MRI T1 plus contrast imagesCTV for Intermediate-to-High Grade Tumors ≥ 8 cm: CTV = GTV and suspicious edema (defined by MRI T2...