How would you manage a patient with isolated metastatic high grade sarcoma to inguinal and external nodes in a patient with BRCA+ mutation?

This patient had resection of the primary, requiring multiple resections to obtain an R0 resection, followed by adjuvant radiation to the primary. They did not experience local recurrence.

Answer from: Medical Oncologist at Academic Institution

Ovarian cancer treatments can work for BRCA2+ leiomyosarcoma.This has been published (Seligson et al., PMID 30541756) and I have had a couple of patients with BRCA2+ LMS. I had no luck with PARP inhibitors but one tremendous success with cisplatin, which produced a dramatic response in one heavily p...

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Radiation Oncologist at Lovelace Cancer Center
Thank you for your helpful response. This patient ...

Medical Oncologist at Emory University
Nodal disease can be treated with intent to cure. ...

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How would you manage a patient with isolated metastatic high grade sarcoma to inguinal and external nodes in a patient with BRCA+ mutation?

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