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How would you treat someone with unknown primary metastatic SMARCA4 deficient tumor (high-grade tumor with rhabdoid morphology)?
Answer from: Medical Oncologist at Community Practice
Ponatinib might be useful. You might also see if a clinical trial is available.http://clincancerres.aacrjournals.org/content/24/8/1932
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Answer from: Medical Oncologist at Academic Institution
Consider tazemetostat (epigenetic modifier via EZH2 nhibition) via compassionate use program.