Cancer of Unknown Primary

Questions discussed in this category

Can you use NGS panels or ctDNA to help you find organ of origin in the workup of carcinoma of unknown origin?

If so, what alterations would be helpful to narrow the diagnosis?

1 Answer available

When would you offer adjuvant chemotherapy after axillary dissection and RT for an isolated squamous cell carcinoma of an axillary node with unknown primary?

What factors into your decision making and what systemic therapy would you offer?

1 Answer available

In patients with cancer of unknown primary, do you routinely send molecular testing to help determine primary tumor origin?

1 Answer available

How would you treat someone with unknown primary metastatic SMARCA4 deficient tumor (high-grade tumor with rhabdoid morphology)?

2 Answers available

Papers discussed in this category

Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-04-15

Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.

J. Clin. Oncol., 2019 Jan 17

Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling With Carboplatin and Paclitaxel for Patients With Cancer of Unknown Primary Site.

Mol Diagn Ther, 2023 Apr 26

Validation of a Transcriptome-Based Assay for Classifying Cancers of Unknown Primary Origin.

Transl Oncol, 2021 Jan 16

Machine learning analysis using 77,044 genomic and transcriptomic profiles to accurately predict tumor type.

Lancet Oncol, 2016 Aug 27

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.

ESMO Open, 2022 Dec 01

Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics.

Nat Commun, 2022 Aug 02

Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.

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