Can you use NGS panels or ctDNA to help you find organ of origin in the workup of carcinoma of unknown origin?

If so, what alterations would be helpful to narrow the diagnosis?

Answer from: Medical Oncologist at Academic Institution

At least 2 NGS panels available in the US now offer tumor of origin (TO) profiling. Both Tempus and Caris offer such testing. There are other panels out there using different methods such as epigenetic profiling and WGS. How much this testing improves diagnosis and outcomes is not clear and 2 trials...

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Medical Oncologist at FDA U.S. Food and Drug Administration
I wonder what the current evidence supports, the v...

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Can you use NGS panels or ctDNA to help you find organ of origin in the workup of carcinoma of unknown origin?

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