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Does cytotoxic chemotherapy affect the yield of germline testing?
Should testing for germline mutations -- eg. saliva sample -- occur before or after the completion of chemotherapy - or the timing does not matter?
Answer from: Medical Oncologist at Academic Institution
Chemotherapy does not typically affect the yield or accuracy of germline testing for genetic mutations. Germline testing analyzes a person's DNA from a blood sample or other tissue to identify inherited genetic variants. This type of testing focuses on the genetic information that is present in the ...
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