What is the recommended approach for systemic therapy in a patient with metastatic cutaneous squamous cell carcinoma with active autoimmune disease (dermatomyositis)?  

Dermatomyositis can occur with myositis/myasthenia gravis (overlap syndrome). At the Ohio State University Comprehensive Cancer Center, we have established an Immunotoxicity Clinic headed by a rheumatologist, Dr. @Alexa S. Meara. I would recommend engaging with a rheumatologist who is familiar with ...

It depends on how bad the autoimmune disease is. If not a severe case of dermatomyositis, perhaps a crack at anti-PD1 therapy can be undertaken with caution and close follow-ups. If the autoimmune disease requires biologics for immunosuppression, then perhaps anti-PD1 is not the best option. In such...