In what situations would you consider doublet chemotherapy in treatment of a premenopausal de novo metastatic TNBC?

I use a doublet in patients with symptomatic disease or large disease burden.

Shortness of breath or pain from locally advanced disease and significant liver disease burden are typical examples.

These are situations where a higher disease response matters for quality of life and improving symptoms ...

I was able to discuss this case with several colleagues who subspecialize in breast, and it was our good fortune this occurred the week of SABCS so they were able to discuss it amongst their peers as well.

We went with doublet therapy with the goal of getting a timely response to treatment due to the...