How would you treat osteosarcoma that has relapsed with unresectable pulmonary metastatic disease?

Typically, I will discuss with the medical oncology team regarding systemic therapy options available as well as clinical trial options.

With limited numbers of pulmonary metastases, you can consider SBRT and I have used a regimen of 60 Gy/5 fx.

Generally, if unresectable, I would not consider this a curable situation, and the choices of therapy would of course need to balanced with toxicity, quality of life, and potential for improving time to progression.

Ifos/etoposide may be the most likely standard chemo option to provide benefit, but i...

I agree with the comments above. Find a study that is trying to help the patient not only answer scientific questions and therefore is multi-agent or a new creative approach --

Take home is there are no proven therapies for relapsed OST - however, with many years and many OST relapses - my experienc...

Osteosarcoma is a disease for which there has been no progress in 40 years. When relapse presents with unresectable pulmonary metastases while I will offer "standard" treatments, I am always clear that while these may delay progression, they are not curative, nor have any been shown to extend overal...