Would you offer neoadjuvant chemotherapy for a large, but recurrent grade 1-2 myxoid chondrosarcoma of knee which is no longer amenable to limb salvage?  

Conventional wisdom about conventional chondrosarcomas says they are chemotherapy insensitive. However, there is data in this rare subtype of myxoid chondrosarcoma to use standard sarcoma chemotherapy with either doxorubicin alone or as a combo with ifosfamide. A very small case series from Stacchio...

While not directly relevant for this patient, it is also important to keep in mind that RT is quite effective in decreasing LF in chondrosarcoma, particularly in anatomically challenging locations like joints/pelvis/spine where wide margins often cannot be achieved. The benefit of RT (HR 0.23 f...