How would you treat metastatic malignant peripheral nerve sheath tumor in a patient who received adjuvant Adriamycin ( 240 mg/m2) 10 years ago for breast cancer?  

Ifosfamide+Etoposide has activity in MPNST and could be considered in a patient with prior doxorubicin. In general MPNST is treated as other metastatic soft tissue sarcomas. There is still the possibility of giving a doxorubicin containing regimen such as doxorubicin+olaratumab for a couple cycles a...