How do you counsel patients with localized Ewing's sarcoma who wish to stop or cannot complete the full course of 14 cycles of perioperative chemotherapy?  

Ewing sarcoma is sensitive to chemotherapy and studies over time have demonstrated survival benefit with dose intensification. If it can be tolerated with manageable toxicity, then I strongly encourage patients to complete the full course of chemotherapy when the goal of treatment is curative. Inter...