How do you approach a patient with newly diagnosed high-grade osteosarcoma who received maximum cumulative dose of doxorubicin for a soft tissue sarcoma 10 years earlier?  

Unfortunately with sarcomas, we do not have the luxury of thinking in terms of the maximum lifetime dose of doxorubicin. Assuming the patient has acceptable heart function (EF>50%) now and you are treating for curative intent, would proceed with doxorubicin anyway. I add dexrazoxane in a 10:1 dos...

Some chemo is better than no chemo for osteosarcoma.That is what is known. After the first randomized study establishing that chemo was effective at improving survival for OS, all subsequent randomized studies have been statistical ties. No regimen or schedule or dose or drug has been proven to be b...

In planning for treatment for your patient, you might consider the following articles. Anninga et al., PMID 21703851 - Of cisplatin, ifosfamide, doxorubicin, methotrexate, and etoposide, using 3 chemotherapeutic agents is better than 2, but 4 isn't better than 3 in treating osteosarcoma. Etoposide ...