Are there special considerations when treating a patient with sarcomatoid SCC of the head and neck?  

Sarcomatoid HNSCC is generally considered a less uncommon but more aggressive version of conventional HNSCC, thought to be at least in part arise as de-differentiated high-grade SCC. While they have been reported in some small studies to arise within a previously irradiated region, these epithelial ...

These are less radiosensitive. When a patient chooses non-surgical management, I always try to intensify by adding chemo and/or accelerating radiotherapy (BID once a week or BID daily). I do this even for a T1 glottic primary. I have seen this type of histology not respond to chemoradiotherapy. ...