How would you manage a Grade II IDH mutant astrocytoma with otherwise low risk features, but gemistocytic histology?  

Not sure there is a right answer for this one - in general, for an IDH mutant grade 2 astrocytoma with low risk features, I would consider observation. If all else is low risk with the exception of gemistocytic histology, I may still consider observation and counsel the patient about an increased ri...