How would you manage a patient with ER+ HER-2+ metastatic disease on T-DM1 with NED for over 2 years, now with an isolated recurrence that is ER+ but HER-2 negative?

She developed isolated paraspinal recurrence that is not amenable for local therapies including RT.

Answer from: Medical Oncologist at Community Practice

Odd presentation. Would talk to the pathologist about the receptors status and consider repeating those. If this is truly ER+ and HER2 negative, I would keep the T-DM1 going and add an AI

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Medical Oncologist at Siri Onclogy and hematology Infusion Service
this is situation where one would also add local t...

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How would you manage a patient with ER+ HER-2+ metastatic disease on T-DM1 with NED for over 2 years, now with an isolated recurrence that is ER+ but HER-2 negative?

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