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Topics:
Hematologic Malignancies • Radiation Oncology • Medical Oncology • Lymphoma • Internal Medicine • Hematology
How would you manage a pre-menopausal woman with extranodal marginal zone lymphoma confined to the bladder wall?
Given pelvic RT is likely to induce ovarian dysfunction/menopause, would you consider systemic options?
Answer from: Radiation Oncologist at Academic Institution
Marginal Zone Lymphoma (MZL) when localized is curable in most instances with modest doses of RT (24-30 Gy), perhaps even less when the primary site is the orbit. It typically responds to rituximab but relapses occur in most cases. Therefore, definitive RT is the treatment of choice in the great maj...
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Answer from: Medical Oncologist at Academic Institution
The lesion is described as "confined to the bladder wall". No strong epidemiological data links bladder wall marginal zone lymphoma with a particular underlying infection, a situation that is not uncommon in other extranodal sites of disease. I agree with the concern about the use of radiation thera...