How would you manage a well differentiated neuroendocrine cancer without a known primary that is not clearly resectable but not overtly metastatic?

NENs of unknown primary are relatively rare, and they constitute less than 5% of all CUPs. Previous series review showed that NENs with an unknown primary site account for 10-14% of all NENs. Most of them present with liver mets, and a majority of these represent gastroenteropancreatic NETs.

Clinica...

If the situation to which you are referring is a mesenteric mass with an occult primary in the luminal gut, then I do think that an Octreoscan or a gallium-68 DOTATATE PET/CT (with preference for the latter) can be used to assess the patient's candidacy for somatostatin analogue therapy and, later, ...