How would you modify neoadjuvant chemotherapy for a stage 2-3 triple negative breast cancer who has baseline grade 2-3 neuropathy?  

There are a few options I would consider. First, I would administer 4 cycles of dose-dense AC - assuming she has normal cardiac function at baseline - which typically has no significant neurotoxicity. If the patient has a very good response, I might stop there and send her to surgery. If she ha...

The grade 2-3 chronic neuropathy poses a challenge for taxane chemotherapy.  I would not use taxane in this setting.  It would be helpful to know what is the etiology for the neuropathy and whether the comorbid condition also put her at a risk for anthracycline related cardiac toxicities. ...

Depends on the degree of the pre-existing neuropathy and if related to DM can be monitored or the dose  altered in any case I would have a discussion with the patient and monitor closely if giving a taxane