Please select the option that best describes you:
Topics:
Breast Cancer • Radiation Oncology
How would you treat a large-cell neuroendocrine carcinoma of the breast with bulky axillary involvement with good response to neoadjuvant chemo followed by mastectomy/ALND?
Would you consider traditional breast doses or higher? Would you consider treating only the axilla if the mastectomy specimen showed widely-negative margins?
Answer from: Radiation Oncologist at Community Practice
I would favor comprehensive treatment as uncommon disease and has poor outcome and would err on side of over treatment
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Answer from: Radiation Oncologist at Academic Institution
Agreed, I would treat comprehensively. In terms of dose, not much data but I would use standard doses unless concerns for gross or microscopic disease, though in this case margins are widely negative.