How would you treat a patient with metastatic neuroendocrine carcinoma of the gallbladder with early relapse after platinum doublet?  

By describing the tumor as a Neuroendocrine carcinoma one implies that the tumor is poorly differentiated and high grade.  This is often described as extra-pulmonary small cell lung cancer or high grade GI NEC.  There are no standard second line regimens.  Options are to treat similar...