How would you treat a residual mediastinal mass in patients with a mediastinal germ cell tumor with an incomplete response to primary chemotherapy with BEPx4?

i.e. gross disease on scans that is too diffuse to be removed completely and/or decreasing but not normal markers

Do you pursue close surveillance, second line chemotherapy, or surgical resection?

Answer from: Medical Oncologist at Academic Institution

Several comments:1. VIP is preferred over BEP for PMNSGCT if there will be consideration for extensive mediastinal resection (JCO 34:4445,2016)2. Patient should be evaluated at a center with experienced and skilled thoracic surgical oncology to determine if patient is truly inoperable.3. Need more i...

Comments

Medical Oncologist at University of Mississippi Medical Center
Thank you very much for your reply. To addre...

Medical Oncologist at Indiana Univ Simon Cancer Center
There is never a problem with a declining marker, ...

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How would you treat a residual mediastinal mass in patients with a mediastinal germ cell tumor with an incomplete response to primary chemotherapy with BEPx4?

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