If a patient achieves excellent clinical/radiographic response to neoadjuvant THP, would you omit AC and proceed with surgery?   

If a patient has had only 4 cycles of THP (similar to the NeoSphere Trial preoperative component), then the standard of care is still to proceed with anthracycline-based therapy as we do not yet know if the favorable outcome associated with pCR applies to abbreviated therapy.  However, for a pa...