If a patient with a germ cell tumor has such an event thrombotic events on BEP, is it safe to re-challenge with BEP therapy?  

If a patient has an acute thrombotic event, the patient would subsequently be treated with an anticoagulant. These events are most commonly venous thrombi or thromboembolisms but arterial thrombotic events also occur. If the patient is appropriately anticoagulated based on the specifics of the event...

There is always risk and benefit with any form of cancer treatment. Generally speaking, we have rechallenged patients with BEP following a single thromboembolic episode and usually but not always without further problems. However that is dependent upon the severity of the event and the nature of the...

I would add to Dr Einhorn and Gilligan's posts that a good number of these events are related to (often unnecessary) central venous catheters.  If there is a clearly inciting thrombogenic situation such as upper extremity PICC or PORT, we remove the offending line, proceed with anticoagulation ...