If memantine were started 6 weeks after completion of radiation to base of skull, would you expect any potential benefit?   

There is currently no credible high-quality data to support the use of memantine in focal brain RT for primary or metastatic brain tumors, regardless of whether the hippocampus is in the radiation field. Therefore, I would not prescribe memantine during or after RT in such a clinical setting. In my ...

I liberally prescribe memantine to patients with cranial radiation (not only WBRT) but I would not start memantine 6 months post-radiation. I believe that the damage is mostly done by then and the evidence for drug treatments once the cognitive effects of radiation have set in are not supportive of ...