If using durvalumab/tremelimumab for advanced HCC, must the tremelimumab be given with the first cycle of durvalumab?

Understandably, one may be nervous about the use of tremelimumab because of prior experience with other CTLA4 checkpoint inhibitors like ipilimumab. With tremelimumab being given only once, such concerns would be less or dissipate all together. Sure, durvalumab plus tremelimumab should be given toge...

I do my best to follow the clinical data and would dose medications as they were developed in the context of clinical trials.