In a patient with oligometastatic, recurrent Grade 2, ER+, MSI-high endometrioid adenocarcinoma who has a single, resectable metastasis to bone, what systemic therapy would you recommend and how would you time it in relation to possible surgery?  

Would you offer pembrolizumab vs hormonal therapy? The patient cannot receive another taxane due to debilitating neuropathy.

Would you offer this in a neoadjuvant vs adjuvant fashion with regards to surgical resection? Alternatively, would you favor radiation therapy over resection?