In a premenopausal HR+ patient with pT2 pN0(i+) disease and RS<16, does the presence of isolated lymph node tumor cells affect your decision to avoid chemotherapy?

Oncotype score in this case was 14.

Answer from: Medical Oncologist at Academic Institution

No, I would consider this node negative disease, aligning with the AJCC staging. I would recommend no chemotherapy for a RS of <16 in a premenopausal woman based on the results from TAILORx, which indicated no benefit from chemotherapy in those with low recurrence scores.

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Medical Oncologist at Wellspan Health
Dr. @Wisinski, do you consider pN0(i+) as a nodal ...

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In a premenopausal HR+ patient with pT2 pN0(i+) disease and RS<16, does the presence of isolated lymph node tumor cells affect your decision to avoid chemotherapy?

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