In patients with HTLV-1 associated acute T-cell leukemia, is there any clear benefit of adding antivirals?

If yes, would you go with Zidovudine monotherapy versus combining with interferon-alpha? And what would be the preferred dose and duration?

Answer from: at Academic Institution

There is no virologic rationale for using antivirals to treat HTLV-1-associated malignancies. HTLV-1 is a "transforming" retrovirus that directly causes cancer by oncogene expression. There is no significant "lytic" replication occurring once the cancer has manifested. Antiretrovirals only work with...

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at University of Mississippi School of Medicine
Thank you Dr. @Winslow, that's helpful.

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In patients with HTLV-1 associated acute T-cell leukemia, is there any clear benefit of adding antivirals?

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