Is anticoagulation a relative contraindication to atezolizumab/bevacizumab for advanced HCC?  

Anticoagulation is considered safe with bevacizumab unless the patient has an increased of bleeding; as such, any varices should have been adequately treated before treatment with atezolizumab/bevacizumab; I would also avoid anticoagulation and atezo/bev concurrently in patients with platelet count ...

It is not, in clinical practice, which has accepted to evaluate risk-benefit ratio, in case of other anti-angiogenesis agents such as all other targeted therapy in HCC

I do feel that it is. Things to take into account are the reason for anticoagulation and duration. If a patient is on prophylactic anticoagulation for atrial fibrillation, it is probably ok to use bevacizumab cautiously. I consider arterial thrombosis or recent venous thromboses as relative contrain...